Mechanism-driven metabolic reprogramming

Our approach goes beyond symptom management. We target the fundamental cellular pathways that regulate metabolism, energy production, and inflammatory response.

By understanding and modulating these pathways at the molecular level, we develop therapies that address the root causes of metabolic and neurodegenerative disorders.

Three interconnected pathways

Our therapeutic strategy targets multiple cellular mechanisms that work synergistically to restore metabolic health.
white and black abstract painting
white and black abstract painting
Mitochondrial Function

Mitochondria are the powerhouses of cells, and their dysfunction is central to metabolic disease. Our approach enhances mitochondrial biogenesis, improves electron transport chain efficiency, and reduces oxidative stress to restore cellular health.

  • Increased mitochondrial biogenesis

  • Enhanced oxidative phosphorylation

  • Reduced mitochondrial ROS production

  • Improved mitochondrial quality control

Cellular Energy Regulation

We target key metabolic pathways that control how cells generate and utilize energy. By modulating AMP-activated protein kinase (AMPK) and related signaling cascades, our therapies restore cellular energy balance and enhance metabolic flexibility.

  • Activation of AMPK signaling

  • Enhanced glucose uptake and utilization

  • Improved fatty acid oxidation

  • Restoration of metabolic homeostasis

purple and pink plasma ball
purple and pink plasma ball
gray concrete wall inside building
gray concrete wall inside building
Inflammatory Signaling Pathways

Chronic inflammation drives metabolic dysfunction and tissue damage. We modulate key inflammatory pathways including NF-κB and inflammasome signaling to reduce systemic inflammation and protect metabolic tissues.

  • Inhibition of NF-κB activation

  • Suppression of NLRP3 inflammasome

  • Reduced pro-inflammatory cytokine production

  • Protection against metabolic inflammation

A Comprehensive, multi-targeted strategy

By simultaneously addressing energy metabolism, mitochondrial health, and inflammatory signaling, our therapies provide comprehensive metabolic reprogramming that goes far beyond single-target approaches. This integrated strategy is the foundation of our lead program, Horeb-101.